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Properties of kallikrein‐containing granules isolated from the submaxillary gland of the guinea‐pig
Author(s) -
Bhoola K. D.,
Heap P. F.
Publication year - 1970
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1970.sp009218
Subject(s) - kallikrein , serous fluid , submaxillary gland , submandibular gland , amylase , guinea pig , chemistry , organelle , saliva , salivary gland , ultrastructure , proteases , biochemistry , protease , enzyme , biology , endocrinology , anatomy
1. Granular fractions of high purity consisting of subcellular kallikrein‐ and amylase‐storing organelles have been isolated from homogenates of guinea‐pig submaxillary gland. 2. The isolated kallikrein‐ and amylase‐containing granules closely resembled secretory granules observed in situ in serous acinar cells in intra‐granular appearance, size and histochemical reaction. 3. The subcellular, histochemical and ultrastructural studies indicate that the serine protease, kallikrein, is like amylase an exocrine enzyme with a functional role in saliva.