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The effects of salicylate on temperature regulation in the rabbit
Author(s) -
Cranston W. I.,
Luff R. H.,
Rawlins M. D.,
Rosendorff C.
Publication year - 1970
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1970.sp009117
Subject(s) - sodium salicylate , antipyretic , chemistry , anesthesia , pharmacology , rabbit (cipher) , medicine , analgesic , statistics , mathematics
1. A stable pyrexia has been produced in rabbits by intravenous injection of leucocyte pyrogen followed by a continuous infusion. 2. Intravenous sodium salicylate, given 4 hr after the start of pyrogen infusion, induced rapid and progressive defervescence. The rate of fall of temperature was dose dependent. 3. Intravenous injection of sodium salicylate had no effect on the temperature of afebrile rabbits. 4. The intraventricular injection of small doses of sodium salicylate, given 4 hr after the start of a pyrogen infusion, caused a rapid, dose‐dependent defervescence, but had no significant effect on the temperature of afebrile rabbits. 5. Salicylates exert at least part of their antipyretic activity through an action on the central nervous system.