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Further study of the role of calcium in synaptic transmission
Author(s) -
Katz B.,
Miledi R.
Publication year - 1970
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1970.sp009095
Subject(s) - neurotransmission , calcium , tetrodotoxin , depolarization , biophysics , synaptic augmentation , neuroscience , chemistry , squid , calcium in biology , biology , biochemistry , receptor , organic chemistry , ecology
1. The effect of calcium on synaptic transmission has been studied by intracellular recording of pre‐ and post‐synaptic potential changes in the stellate ganglion of the squid. 2. For a given presynaptic ‘input’ (propagated spike, or local depolarizing pulse after tetrodotoxin treatment), the post‐synaptic response increases with external calcium concentration [Ca] o in a highly non‐linear fashion, indicating that transmitter output varies with more than the second power of [Ca] o over a certain concentration range.