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Influence of oestrogen on thyroid function in the ewe
Author(s) -
Falconer Ian R.
Publication year - 1970
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1970.sp009025
Subject(s) - ovariectomized rat , endocrinology , medicine , thyroid , estrous cycle , thyroid function , hormone , chemistry , biology
1. Thyroid activation at oestrus occurs in several species, which may be related to oestrogen secretion occurring at the same time. In the ewe this relationship has been examined by measuring thyroid activity before and after oestrogen administration. 2. Measurements have been made of thyroid 131 I release rate and protein‐bound 131 I concentration in the plasma in normal and ovariectomized ewes and of protein‐bound 125 I in plasma from thyroid vein blood in ewes with exteriorized thyroid glands. 3. No evidence of an activation of the thyroid by oestrogen was observed in immature ewes or adult oestrous cycle, anoestrous or ovariectomized ewes, given oestrone or oestradiol dibenzoate in doses of 25–1000 μg by injection. 4. It was concluded that oestrogen may not be responsible for thyroid activation observed in normal oestrous ewes.