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The effect of acute changes in haematocrit in the anaesthetized dog on the volume and character of the urine
Author(s) -
Nashat F. S.,
Scholefield F. R.,
Tappin J. W.,
Wilcox C. S.
Publication year - 1969
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1969.sp008966
Subject(s) - diuretic , diuresis , free water clearance , chemistry , dextran , sodium , blood volume , renal function , blood pressure , anesthesia , medicine , extracellular fluid , saline , heart rate , endocrinology , extracellular , chromatography , biochemistry , organic chemistry
1. Acute changes in haematocrit were produced by exchange transfusion of dextran‐in‐saline or packed red cells. 2. There were no significant changes in glomerular filtration rate, blood pressure, central venous pressure, heart rate, respiratory rate, blood volume or extracellular fluid volume following the exchange transfusions. 3. Urine volume increased after haemodilution but decreased after haemoconcentration. 4. The diuresis after haemodilution occurred despite an infusion of ADH or alcohol. Thus it could not be attributed to a change in circulating ADH level. 5. There were two types of diuresis. The ‘water diuretic’ response was characterized by an increase in free water clearance with a reduction in urinary sodium concentration; the ‘sodium diuretic’ response by an increase in urinary sodium concentration but no change, or a fall, in free water clearance. 6. The results were related to changes in medullary osmotic gradient found by other workers to occur when medullary blood flow rate is altered.