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Hypoxaemia and aortic chemoreceptor function in foetal lambs
Author(s) -
Dawes G. S.,
Duncan Sheila L. B.,
Lewis B. V.,
Merlet Claudie L.,
Owen-Thomas J. B.,
Reeves J. T.
Publication year - 1969
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1969.sp008745
Subject(s) - chemoreceptor , constriction , medicine , reflex , carotid sinus , cardiology , anesthesia , blood pressure , anatomy , receptor
1. In foetal lambs the effect of raising and lowering arterial P O 2 (by varying the O 2 content of the maternal inspired gas mixture) was studied in order to determine whether the systemic arterial chemoreceptors regulated the circulation. 2. From 0·7 of term relative hypoxaemia (e.g. reducing carotid P O 2 from 40 to 20 mm Hg) caused a rise of arterial pressure and femoral vaso‐constriction. These changes were unaffected or even increased by bilateral section of the nerves from the carotid sinus and body. They were abolished by section of the vagi or aortic nerves. 3. It is concluded that in foetal lambs during the last third of gestation the circulation is under reflex control by the aortic chemoreceptors.