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Sodium ions and the secretion of catecholamines
Author(s) -
Banks P.,
Biggins Rosemary,
Bishop R.,
Christian B.,
Currie N.
Publication year - 1969
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1969.sp008722
Subject(s) - secretion , endocrinology , medicine , sodium , stimulation , perfusion , chemistry , potassium , intracellular , basal (medicine) , biology , biochemistry , organic chemistry , insulin
1. Perfusion of bovine adrenal glands with a potassium‐free Tyrode solution results in an increased spontaneous release of catecholamines and an increased response to stimulation with carbamylcholine. 2. Perfusion with a Tyrode solution containing 70 m M ‐KCl causes a marked secretion of catecholamines and a subsequent inhibition of secretion in response to stimulation with carbamylcholine. 3. Perfusion with sodium‐free media abolishes or severely reduces the secretory response of the gland to carbamylcholine and to 70 m M ‐KCl although the basal secretion shows an initial rise. 4. Perfusion with sodium‐deficient media permits some retention of the secretory response. 5. A possible role for intracellular sodium ions in the secretion of catecholamines is discussed.