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The effect of local blockage of motor nerve terminals
Author(s) -
Katz B.,
Miledi R.
Publication year - 1968
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1968.sp008675
Subject(s) - tetrodotoxin , motor nerve , terminal (telecommunication) , neuroscience , neuromuscular transmission , neuromuscular junction , chemistry , anatomy , biophysics , biology , medicine , anesthesia , computer science , telecommunications
1. Electrophoretic application of tetrodotoxin (TTX) was used to study the effect of localized blockage of impulses in motor nerve terminals. 2. Under suitable conditions it can be shown that local production of end‐plate potentials ceases distal to the site of TTX application, while it continues without diminution at proximal sites of the same terminal arborization. 3. It is concluded that electrotonic spread of an action potential wave along a motor nerve terminal is insufficient to elicit transmitter release. Active propagation in the terminals is an essential requirement for neuromuscular transmission.