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A study of the end‐plate potential in sodium‐deficient solution
Author(s) -
Kordaš M.
Publication year - 1968
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1968.sp008594
Subject(s) - curare , sodium , chemistry , membrane , biophysics , membrane potential , potential difference , rectification , voltage , electrical engineering , electrode , biochemistry , anesthesia , biology , medicine , engineering , organic chemistry
1. The effect of anticholinesterases in lengthening the end‐plate potential is much more pronounced in a low‐sodium solution than in an ordinary Ringer‐curare solution. 2. To investigate this difference, intracellular recordings of end‐plate potentials and of end‐plate currents in voltage‐clamped muscle fibres were used. 3. It was found that the very large lengthening of the end‐plate potential in a low‐sodium solution was due to a combination of three factors: (i) lengthening of the underlying end‐plate current, (ii) an increased membrane resistance and (iii) marked inward‐going (anomalous) rectification of the muscle membrane.