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The effect of infusions of plasma and of saline on the renal response to water‐loading in sodium‐depleted dogs
Author(s) -
Coxon R. V.,
Ramsay D. J.
Publication year - 1968
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1968.sp008578
Subject(s) - diuresis , saline , sodium , chemistry , body weight , natriuresis , peritoneal dialysis , endocrinology , medicine , kidney , anesthesia , organic chemistry
1. Infusion of 150 ml. of plasma to dogs acutely depleted of sodium chloride by peritoneal dialysis with glucose (5 g/100 ml.) does not restore their ability to respond by diuresis when given 2·5% body weight of water by mouth. 2. Infusion of 300 ml. of saline (0·73g NaCl/100 ml.) to these animals results in a brisk increase in urinary flow. 3. Infusion of 100 ml. of saline (0·73g NaCl/100 ml.) to sodium‐depleted dogs restores their ability to respond to a water‐load of 2·5% of body weight by diuresis. 4. The results are discussed and a tentative explanation put forward.