The effect of infusions of plasma and of saline on the renal response to water‐loading in sodium‐depleted dogs

1. Infusion of 150 ml. of plasma to dogs acutely depleted of sodium chloride by peritoneal dialysis with glucose (5 g/100 ml.) does not restore their ability to respond by diuresis when given 2·5% body weight of water by mouth. 2. Infusion of 300 ml. of saline (0·73g NaCl/100 ml.) to these animals results in a brisk increase in urinary flow. 3. Infusion of 100 ml. of saline (0·73g NaCl/100 ml.) to sodium‐depleted dogs restores their ability to respond to a water‐load of 2·5% of body weight by diuresis. 4. The results are discussed and a tentative explanation put forward.