Premium
Sodium movements in denervated muscle and the effects of antimycin A
Author(s) -
Creese R.,
El-Shafie A. L.,
Vrbová Gerta
Publication year - 1968
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1968.sp008559
Subject(s) - sodium , diaphragm (acoustics) , antimycin a , chemistry , medicine , stimulation , endocrinology , denervation , potassium , acetylcholine , anatomy , biology , biochemistry , mitochondrion , physics , organic chemistry , acoustics , loudspeaker
1. Fibre sodium in rat diaphragm exchanged at a faster rate in muscles which had been denervated 8 days previously. The half‐time was 3·7 min for outward movement in denervated muscles and 5·1 min in controls. 2. The inward movement of sodium was also faster in denervated muscle as compared with controls, and the calculated permeability to sodium was approximately doubled. 3. In the presence of antimycin A (1·8 × 10 −5 M ), the outward movement of sodium in denervated diaphragm was slowed and the fibres gained sodium and lost potassium. 4. Antimycin markedly reduced the twitch produced by stimulation of denervated diaphragm, and also the response to acetylcholine. Similar effects were found in denervated tibialis anterior of the cat.