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The effect of oestrogen and progesterone on the pressor action of angiotensin in the rat
Author(s) -
Hettiaratchi E. S. G.,
Pickford Mary
Publication year - 1968
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1968.sp008517
Subject(s) - endocrinology , medicine , pressor response , angiotensin ii , renin–angiotensin system , estrous cycle , pregnancy , chemistry , blood pressure , biology , heart rate , genetics
1. A comparison was made between the pressor responses to angiotensin in rats during different stages of the oestrous cycle, pregnancy, pseudopregnancy and also following oestrogen and progesterone treatment. 2. No evidence for an effect of oestrogen on the response to angiotensin was found. 3. Pregnancy and pseudopregnancy were found to diminish the pressor response to angiotensin. 4. Progesterone treatment also diminished the response to angiotensin. 5. It is suggested that the decrease in pressor response in pregnancy and pseudopregnancy is attributable to progesterone. 6. The possible mode of action of progesterone is discussed.