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A renally active substance from heart muscle and from blood
Author(s) -
Ilett K. F.,
Lockett Mary F.
Publication year - 1968
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1968.sp008497
Subject(s) - aldosterone , venous blood , medicine , chemistry , steroid , endocrinology , hormone
1. A steroid‐like compound has been isolated from cat heart muscle by thin‐layer chromatography. 2. This compound has been characterized by measurement of its R F values in two solvent systems. 3. No similar substance could be detected in the 1 hr venous outputs of cat adrenals. 4. It could not be detected in heart‐lung circuit blood when the heart had been perfusing for 1¼‐1½ hr at constant venous input and peripheral resistance. The compound was however extractable from the circuit blood 10‐15 min after reduction in venous input. 5. The actions of this compound on the isolated kidney resemble those of aldosterone but are of much shorter latency. 6. The heart substance differs from aldosterone in R F values and has more than 10 times the renal activity of aldosterone when the two substances are equated (visually) for ability to reduce blue tetrazolium.