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Temperature changes produced by the injection of catecholamines and 5‐hydroxytryptamine into the cerebral ventricles of the conscious mouse
Author(s) -
Brittain R. T.,
Handley S. L.
Publication year - 1967
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1967.sp008332
Subject(s) - phentolamine , isoprenaline , hypothermia , medicine , propranolol , endocrinology , chemistry , dopamine , catecholamine , norepinephrine , adrenergic , receptor , stimulation
1. Changes in temperature were determined following injection of noradrenaline, adrenaline, isoprenaline, dopamine and 5‐hydroxytryptamine (5‐HT) into the cerebral ventricles of the conscious mouse. 2. Noradrenaline (1‐20 μg) and dopamine (10‐160 μg) caused falls in body temperature. Adrenaline (1‐20 μg) caused a slight and transient rise in body temperature followed by a fall. Isoprenaline (5‐20 μg) caused a rise in body temperature, hypothermia only occurring after very high doses (200 μg) of this catecholamine. 3. α‐ and β‐adrenergic blocking agents, phentolamine (> 2 μg) and propranolol (> 5 μg) respectively, caused falls in body temperature when injected into the cerebral ventricles of the mouse. 4. Specific drug antagonism studies were limited owing to the intrinsic effects of the α‐ and β‐adrenergic blocking agents. However, some evidence was obtained to indicate that noradrenaline mediated its effects through a central α‐type adrenergic receptor. 5. 5‐HT (10‐160 μg) caused a fall in body temperature. The action of this indoleamine and the catecholamines in regard to thermoregulatory function is discussed.