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Neurohypophysial peptide interaction with magnesium in avian vascular smooth muscle *
Author(s) -
Somlyo Andrew P.,
Somlyo Avril V.,
Woo Chi-Yuan
Publication year - 1967
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1967.sp008323
Subject(s) - magnesium , vascular smooth muscle , peptide , chemistry , medicine , endocrinology , biophysics , biology , microbiology and biotechnology , anatomy , smooth muscle , biochemistry , organic chemistry
1. The contractile responses of helically cut vascular strips of chickens to vasoactive agents were studied. 2. Large pulmonary arteries were contracted by neurohypophysial peptides, but not by angiotensin, acetylcholine, histamine, 5‐hydroxytryptamine, bradykinin or eledoisin. The activity of oxytocin was greater than that of arginine vasopressin. 3. Vasodilator effects of oxytocin upon small (200‐500 μ diameter) mesenteric and muscular arteries were demonstrable, but inconsistent. 4. Magnesium potentiated in a parallel fashion the vasoconstrictor effects of oxytocin and of arginine vasopressin. 5. Deamino‐oxytocin was potentiated by magnesium. This finding suggests a difference between the peptide‐protein interactions of tissue receptors and those of neurophysin.