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Some observations on ‘autoregulatory escape’ in cat intestine
Author(s) -
Baker Rosemary,
Mendel D.
Publication year - 1967
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1967.sp008204
Subject(s) - splanchnic , splanchnic nerves , stimulation , blood flow , medicine , endocrinology , intestinal motility , chemistry , oxygen , norepinephrine , venous blood , anatomy , motility , biology , dopamine , microbiology and biotechnology , organic chemistry
1. ‘Autoregulatory escape’ (Folkow, Lewis, Lundgren, Mellander & Wallentin, 1964 a ) in which intestinal blood flow escapes from the constrictor influence of splanchnic nerve stimulation, was investigated in the cat. Measurements were made of intestinal blood flow, movements and portal venous pH and oxygen content. 2. ‘Autoregulatory escape’ was observed with sympathetic nerve stimulation and noradrenaline infusion. It did not occur during haemorrhage. 3. The recovery of flow during noradrenaline infusion could not be explained by changes in intestinal motility or loss of effect of noradrenaline due to changes in portal venous hydrogen ion concentration. 4. During a noradrenaline infusion there was a reduction in oxygen consumption associated with a fall in blood flow. During the period of ‘autoregulatory escape’, however, oxygen consumption increased. The significance of these observations is discussed.