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Excitation of afferent cardiac sympathetic nerve fibres during myocardial ischaemia
Author(s) -
Brown A. M.
Publication year - 1967
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1967.sp008191
Subject(s) - coronary artery occlusion , afferent , coronary occlusion , medicine , occlusion , stimulation , cardiology , stimulus (psychology) , ischemia , anesthesia , psychology , psychotherapist
1. Occlusion of the main left coronary artery of lightly anaesthetized cats provoked a pseudaffective reaction. The afferent pathway was in the cardiac sympathetic nerves. 2. The compound action potential evoked in the inferior or middle cardiac nerves by stimulation of the thoracic sympathetic trunk contained two elevations, a small A δ wave and a much larger sC wave. Occasionally a B wave was present. 3. During coronary occlusion, the A δ elevation was reduced by 35‐55%, indicating afferent activity in these fibres. Multifibre preparations also showed increased afferent discharge during occlusion. 4. It seems probable that the afferent activity in these fibres was mainly responsible for signalling the pseudaffective response elicited by coronary occlusion. 5. Myocardial ischaemia produced by coronary occlusion was probably the stimulus for the increased activity.