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The action of dopamine on neurones of the caudate nucleus
Author(s) -
McLennan H.,
York D. H.
Publication year - 1967
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1967.sp008175
Subject(s) - caudate nucleus , dopamine , acetylcholine , stimulation , chemistry , substantia nigra , neuroscience , inhibitory postsynaptic potential , cats , phenoxybenzamine , medicine , endocrinology , dopaminergic , biology , receptor
1. Dopamine applied iontophoretically to neurones of the caudate nucleus of cats caused excitation of some (9% of those encountered) and depression of others (60%). Some cells have been found affected both by dopamine and by acetylcholine. 2. The effects of dopamine could be prevented by the previous iontophoretic administration of phenoxybenzamine, but not by dichloroisopropylnoradrenaline. 3. Responses evoked in caudate neurones by electrical stimulation of substantia nigra were depressed by dopamine. No evidence for enhancement of the effects of nigral stimulation through the application of dopamine were detected. 4. Stimulation of nucleus centromedianus thalami depressed firing of caudate neurones. 5. The hypothesis that dopamine may act as an inhibitory synaptic transmitter within the caudate is put forward.