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The regional distribution of the nerve‐stimulating phosphopeptide (nerveside, substance B) in the central nervous system
Author(s) -
Toh C. C.
Publication year - 1967
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1967.sp008149
Subject(s) - cerebrum , diencephalon , midbrain , pons , cerebral cortex , cerebellum , thalamus , hypothalamus , central nervous system , medulla oblongata , caudate nucleus , neuroscience , hippocampus , cortex (anatomy) , medulla , chemistry , biology , endocrinology
1. The nerve‐stimulating phosphopeptide, nerveside, is present mainly in the cerebrum and brain stem, while the cerebellum contains only a trace amount of it. 2. Nerveside is uniformly distributed over all parts of the cerebral cortex. 3. The cerebral cortex contains the greatest concentration of nerveside. If the nerveside activity of 1 g cerebral cortex is expressed as 100 then the relative activities of the other parts of the C.N.S. are hippocampus 41, caudate nucleus 21, diencephalon (without hypothalamus) 24, midbrain 19, pons 7, medulla 12 and cerebellum 6. 4. The nerveside activity of the hypothalamus is the same as that of the cerebral cortex. 5. The pattern of distribution of nerveside in the C.N.S. suggests that it may be part of a corticipetal or corticifugal system.