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The effect of beta adrenergic receptor blockade on the vasodilator response in the forearm to voluntary hyperventilation
Author(s) -
Brick I.,
Hutchison K. J.,
Roddie I. C.
Publication year - 1966
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1966.sp008115
Subject(s) - hyperventilation , blockade , forearm , vasodilation , adrenergic receptor , medicine , adrenergic , beta (programming language) , anesthesia , cardiology , receptor , anatomy , computer science , programming language
1. Blood flow was simultaneously measured by venous‐occlusion plethysmography in both forearms of ten healthy men. 2. Voluntary overbreathing to produce about 8 times the resting ventilation caused a vasodilatation similar in both forearms. 3. When one forearm was treated with an intra‐arterial infusion of propranolol, a beta adrenergic blocking agent, the vàsodilator response was reduced by an average of 28%, the reduction was significant ( P < 0·01). 4. The failure of propranolol to abolish the vasodilator response was not due to incomplete block of beta adrenergic receptors since the dose of propranolol used reversed the vasodilator response to an intravenous infusion of adrenaline. 5. The results suggest that the vasodilator response to voluntary hyperventilation can be explained partly, but not entirely, by the release into the circulation of an adrenaline‐like substance.