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Recovery of responsiveness of cells of lateral geniculate nucleus of rat
Author(s) -
Burke W.,
Sefton Ann Jervie
Publication year - 1966
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1966.sp008084
Subject(s) - neuroscience , inhibitory postsynaptic potential , stimulation , visual cortex , lateral geniculate nucleus , nucleus , depolarization , cortex (anatomy) , axon , chemistry , biology , biophysics
1. Recovery of responsiveness of single cells in lateral geniculate nucleus of rat has been determined in both P and I cells. There are three types of recovery curve among P cells; ( a ) early recovery, ( b ) early partial recovery followed by depression and then complete recovery, ( c ) prolonged depression followed by cyclic recovery. Type ( c ) is by far the commonest recovery curve. In contrast to the spike in a P cell, the synaptic potential recovers to its full amplitude in about 20 msec. All I cells exhibit similar rapid recovery curves after a prolonged depression. 2. Conditioning stimuli applied to visual cortex also produce a prolonged depression in most P cells but I cells can be re‐excited at short intervals from cortex. Decortication does not prevent the prolonged depression of the multineuronal response produced by optic nerve stimulation. 3. A neuronal model is proposed to explain these observations. It is supposed that I cells (interneurones) are innervated by axon collaterals of the P cells (principal cells, projecting to visual cortex) and that the I cells exert an inhibitory influence on the P cells.