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Effects of sodium extrusion and local anaesthetics on muscle membrane resistance and potential
Author(s) -
Harris E. J.,
Ochs S.
Publication year - 1966
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1966.sp008072
Subject(s) - chemistry , membrane potential , ion , procaine , sodium , analytical chemistry (journal) , chromatography , anesthesia , biochemistry , medicine , organic chemistry
1. Membrane potentials and resistances of K‐depleted muscles were measured in the cold and again after warming in K‐containing media so that active ion movements occurred. 2. On warming there was a fall of resistance and a gradual rise of potential which passed through a maximum. Later measurements of resistance in a chloride medium showed that values were, if anything, higher than initially in the warm. 3. The excess potentials measured approximated to those required to induce passive inward movement of the K ions through the measured K resistance. 4. Permeabilities for K + and Cl − were deduced. When cocaine, procaine, amytal or mepyramine were added or when K + was replaced by Rb + in the Cl − ‐free solution the K + permeability was eventually reduced. The same agents led to an enhanced initial response of potential to warming, but later the potentials in Cl − ‐free media fell to less than the K + equilibrium values. 5. A method for obtaining the resistivity of the membrane from measurements made in conditions of non‐linear voltage—current dependence was applied.