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Effects on temperature of monoamines injected into the cerebral ventricles of anaesthetized dogs
Author(s) -
Feldberg W.,
Hellon R. F.,
Myers R. D.
Publication year - 1966
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1966.sp008043
Subject(s) - shivering , cannula , rectal temperature , cerebral ventricle , anesthesia , monoamine neurotransmitter , ventricle , medicine , lateral ventricles , chemistry , anatomy , serotonin , surgery , receptor
1. In dogs anaesthetized with pentobarbitone sodium an injection of adrenaline or noradrenaline into the cerebral ventricles through a cannula implanted into the left lateral ventricle caused a fall in rectal temperature as a result of cessation of shivering, loss of muscle tone, and skin vasodilatation. 5‐Hydroxytryptamine (5‐HT) similarly applied caused shivering and a rise in rectal temperature. 2. The hypothalamus of the dog thus appears to react to the three monoamines in the same way as in the cat, and not as in the rabbit and sheep.