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The effects of hyperventilation on the reflex cardiac response from the carotid bodies in the cat
Author(s) -
Scott Mary J.
Publication year - 1966
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1966.sp008036
Subject(s) - hyperventilation , reflex , carotid body , heart rate , anesthesia , chloralose , medicine , stimulation , bradycardia , ventilation (architecture) , cats , chemoreceptor , blood pressure , arterial blood , reflex bradycardia , mechanical engineering , receptor , engineering
1. Cats were anaesthetized with chloralose and urethane, and ventilated by an artificial intermittent negative pressure applied to the thorax. The carotid body chemoreceptors were isolated and perfused with oxygenated blood. They were stimulated by substituting hypoxic blood obtained from a donor animal. 2. Stimulation of the carotid bodies during constant ventilation caused a bradycardia. When an artificial hyperventilation was induced during carotid body stimulation the heart rate increased. 3. The increase in heart rate during hyperventilation, and while the carotid bodies were being stimulated, was due to at least two mechanisms, first a reflex from the lungs and secondly a fall in arterial blood P CO 2 , both of which accompany the hyperventilation.