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Calcium metabolism in normal and thyro‐parathyroidectomized goats
Author(s) -
Payne J. M.,
Sansom B. F.
Publication year - 1966
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1966.sp007924
Subject(s) - endocrinology , medicine , calcium , thyroidectomy , parathyroidectomy , thyroid , bone resorption , resorption , chemistry , calcium metabolism , parathyroid hormone
1. The effects of thyro‐parathyroidectomy on calcium metabolism in the goat have been investigated using stable calcium balance techniques and the isotopes 45 Ca, 47 Ca and 85 Sr. 2. Thyro‐parathyroidectomized goats, whether receiving supplementary thyroxine or not, are in negative calcium balance, whereas normal or thyroidectomized animals are in positive balance. 3. Gastro‐intestinal absorption of 45 Ca is less in thyro‐parathyroidectomized goats, whether receiving supplementary thyroxine or not, than in either normal goats or thyroidectomized goats receiving thyroxine supplements. 4. The rate of endogenous secretion of calcium into the gastro‐intestinal tract is unchanged by either thyroidectomy or thyro‐parathyroidectomy. Urinary excretion of calcium is also apparently unchanged. 5. The bone calcium accretion rate is reduced to approximately the same extent in thyroidectomized and thyro‐parathyroidectomized goats. Thyroxine supplements restore the bone accretion rate of both groups of animals to normal or greater than normal levels. 6. The bone calcium resorption rate is greater in thyro‐parathyroidectomized goats, whether receiving thyroxine supplements or not, than in either normal goats or thyroidectomized goats receiving thyroxine supplements.