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The relationship between ovulation and the changes in thyroid gland activity that occur during the oestrous cycle in rats, mice and hamsters
Author(s) -
Brown-Grant K.
Publication year - 1966
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1966.sp007922
Subject(s) - ovulation , estrous cycle , endocrinology , medicine , thyroid , luteinizing hormone , endocrine system , hormone , biology
1. When ovulation is prevented by the injection of pentobarbitone on the day of pro‐oestrus in female rats, the expected increases in thyroid‐serum concentration ratio (T/S ratio) for 131 I and in the uptake of 113 I by the thyroid on the day of oestrus do not occur. 2. Ovulation induced by human chorionic gonadotrophin or ovine luteinizing hormone in rats treated with pentobarbitone at pro‐oestrus is not associated with an increase in T/S ratio or 131 I uptake at oestrus. 3. These results support the view that it is the neuro‐endocrine changes at the hypothalamic or pituitary level that lead to ovulation rather than changes in the pattern of ovarian steroid secretion before or at ovulation that are responsible for the increased thyroid activity at oestrus in the female rat. 4. Experimental evidence of an increase in thyroid activity after ovulation in mice and hamsters also supports this view.