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The response of gastric stretch receptors and certain other abdominal and thoracic vagal receptors to some drugs
Author(s) -
Paintal A. S.
Publication year - 1954
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1954.sp005208
Subject(s) - citation , receptor , medicine , computer science , information retrieval , library science
The presence of gastric stretch receptors reported in detail in another paper (Paintal, 1954b) was revealed in the first instance by means of injection of phenyl diguanide into different vascular channels (Paintal, 1954a). This sensitivity is peculiar as the drug did not, in the same or somewhat higher doses, affect other visceral stretch receptors (Paintal, 1953). It, therefore, seemed worth while to study further the responses of gastric stretch receptors to this, and other drugs such as nicotine, lobeline and 5-hydroxytryptamine which are also known to produce reflex effects. An additional point was that in case these drugs did alter the activity of gastric stretch receptors the information so gained would help in the interpretation of the reflex effects of these drugs. It is believed that the gastric stretch receptors with their afferent connexions are responsible for the immediate satiation of hunger and thirst (Paintal 1954b). Since some evidence exists to show that adrenaline and blood sugar level modify oral food intake (Mayer & Bates, 1952), the effects of these two drugs on gastric stretch receptors were also studied. In the course of the investigation certain other abdominal and thoracic receptors sensitive to phenyl diguanide were also encountered. Two of these were located in the intestines and two were probably of pulmonary origin. The presence of pulmonary receptors sensitive to phenyl diguanide confirms the conclusions of Dawes, Mott & Widdicombe (1951).