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Antibodies organ‐specific against the anterior body of the pituitary gland
Author(s) -
Kestner Otto
Publication year - 1938
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1938.sp003602
Subject(s) - anterior pituitary , citation , pituitary gland , computer science , medicine , world wide web , hormone
LAST year I published an investigation on antibodies organ-specific against the thyroid gland [1937]. I treated sheep with intravenous injections of extracts of the thyroid glands of pigs and injected the serum of the sheep into rabbits. After some weeks the basal metabolic rate of these rabbits was lowered. I have observed that the metabolic rate stays at this lowered level for a year. In this paper similar experiments with organ antibodies specific against the anterior body of the pituitary gland are reported. The literature is not discussed, because my method is a new one. Observations in the physiological laboratory in Hamburg had shown, that specific dynamic action (s.d.a.) depends upon the anterior body [Kestner, 1928; Nothhaas & Never, 1930]. I have now determined the s.d.a. in rats before and after injection of an antipituitary serum. The anterior body of oxen was roughly minced and washed thoroughly with Ringer's solution, the residue frozen, finely ground with sand and dissolved in Ringer's solution. A milky solution containing about 60 p.c. of the nitrogen of the gland and only traces of blood was obtained.