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Training of a discrete motor skill in humans is accompanied by increased excitability of the fastest corticospinal connections at movement onset
Author(s) -
Wiegel Patrick,
Leukel Christian
Publication year - 2020
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jp279879
Subject(s) - transcranial magnetic stimulation , neuroscience , motor learning , primary motor cortex , psychology , motor cortex , motor skill , biological neural network , facilitation , physical medicine and rehabilitation , stimulation , medicine
Key points The primary motor cortex (M1) is fundamentally important for the acquisition of skilled motor behaviours. We tested the excitability changes of distinct M1 circuits at movement onset with TMS H‐reflex conditioning. Human subjects trained a discrete spatiotemporal motor skill. Practice was associated with reduced kinematic variability and improved motor performance. Performance improvements were paralleled by task‐specific excitability increases of the fastest corticospinal connections at infragranular layer 5b of M1. No task‐related changes in excitability were observed at supragranular layers. Excitability changes in the fastest corticospinal connections were not directly related to changes in motor performance.Abstract The primary motor cortex (M1) is fundamentally important for the acquisition of skilled motor behaviours. Recent advances in imaging and electrophysiological techniques have improved our understanding of M1 neural circuit modulation in rodents and non‐human primates during motor learning. However, little remains known about the learning‐related changes of distinct elements in the human brain. In this study, we tested excitability changes of different neural circuits (infragranular and supragranular layers) in the M1 of human subjects who underwent training in a discrete spatiotemporal motor skill. Excitability modulations were assessed by recording H‐reflex facilitation from transcranial magnetic stimulation at movement onset. Motor practice improved the consistency of movements and was accompanied by an excitability increase of the fastest corticospinal connections during the initial stages of motor practice. No such excitability changes were observed for training in a simple motor skill and circuits at supragranular layers of M1. Notably, changes in excitability were not associated with changes in motor performance. Our findings could reflect learning‐related increases in the recruitment and/or reorganisation of the fastest corticospinal connections.