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Integration of nicotinic acid adenine dinucleotide phosphate (NAADP)‐dependent calcium signalling
Author(s) -
Guse Andreas H.,
Diercks BjörnPhilipp
Publication year - 2018
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jp275974
Subject(s) - ryanodine receptor , extracellular , biochemistry , chemistry , organelle , nicotinic agonist , microbiology and biotechnology , receptor , calcium signaling , second messenger system , biology , biophysics
Abstract Nicotinic acid adenine dinucleotide phosphate (NAADP) is currently the most potent endogenous Ca 2+ mobilizing second messenger. Upon specific extracellular stimulation, rapid production of NAADP has been observed in different cell types from sea urchin eggs to mammalian cells. More than 20 years after the discovery of NAADP, there is still controversy surrounding its metabolism and target receptors/ion channels and organelles. This article briefly reviews recent developments in the NAADP field. Besides the metabolism of NAADP, this review focuses on assumed organelles and putative targets, e.g. ion channels, with special emphasis on ryanodine receptor type 1 (RyR1) and two‐pore channels (TPCs). The role of NAADP as a Ca 2+ trigger is also discussed and the importance of NAADP in the formation of initial Ca 2+ microdomains is highlighted.