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The role of STIM proteins in neutrophil functions
Author(s) -
Demaurex Nicolas,
Saul Stephanie
Publication year - 2018
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jp275639
Subject(s) - function (biology) , first line , innate immune system , stim1 , biology , immune system , microbiology and biotechnology , computational biology , immunology , neuroscience , medicine , endoplasmic reticulum
Stromal interaction molecule (STIM) proteins regulate store‐operated Ca 2+ entry (SOCE) in innate and adaptive immune cells and participate in the Ca 2+ signals that control the functions of neutrophils, the first line of host defence against bacterial and fungal infections. Loss‐of‐function experiments in animal and cellular models indicate that both STIM1 and STIM2 regulate neutrophil functions, but the complexity of the SOCE machinery and the versatility of neutrophils complicate the evaluation of the results. This review aims to summarize the latest progress in the field, with special attention to the details of the experimental designs. Future study design should aim to improve the standardization of experimental procedures and to provide a more holistic understanding of the role of STIM proteins in neutrophils function.