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Role of nerve–muscle interactions and reactive oxygen species in regulation of muscle proteostasis with ageing
Author(s) -
Vasilaki Aphrodite,
Richardson Arlan,
Remmen Holly,
Brooks Susan V.,
Larkin Lisa,
McArdle Anne,
Jackson Malcolm J.
Publication year - 2017
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jp274336
Subject(s) - proteostasis , skeletal muscle , reactive oxygen species , ageing , sarcopenia , oxidative stress , muscle atrophy , microbiology and biotechnology , biology , chemistry , anatomy , biochemistry , genetics
Skeletal muscle ageing is characterised by atrophy, a deficit in specific force generation, increased susceptibility to injury, and incomplete recovery after severe damage. The hypothesis that increased generation of reactive oxygen species (ROS) in vivo plays a key role in the ageing process has been extensively studied, but remains controversial. Skeletal muscle generates ROS at rest and during exercise. ROS can cause oxidative damage particularly to proteins. Indeed, products of oxidative damage accumulate in skeletal muscle during ageing and the ability of muscle cells to respond to increased ROS becomes defective. The aim of this review is to examine the evidence that ROS manipulation in peripheral nerves and/or muscle modifies mechanisms of proteostasis in skeletal muscle and plays a key role in initiating sarcopenia.