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Factors regulating quiescent stem cells: insights from the intestine and other self‐renewing tissues
Author(s) -
Richmond Camilla A.,
Shah Manasvi S.,
Carlone Diana L.,
Breault David T.
Publication year - 2016
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jp271653
Subject(s) - homeostasis , microbiology and biotechnology , biology , stem cell , small intestine , function (biology) , neuroscience , regenerative medicine , regeneration (biology) , endocrinology
Long‐lived and self‐renewing adult stem cells (SCs) are essential for homeostasis in a wide range of tissues and can include both rapidly cycling and quiescent (q)SC populations. Rapidly cycling SCs function principally during normal tissue maintenance and are highly sensitive to stress, whereas qSCs exit from their quiescent state in response to homeostatic imbalance and regenerative pressure. The regulatory mechanisms underlying the quiescent state include factors essential for cell cycle control, stress response and survival pathways, developmental signalling pathways, and post‐transcriptional modulation. Here, we review these regulatory mechanisms citing observations from the intestine and other self‐renewing tissues.