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Sodium and calcium regulation in cardiac myocytes: from molecules to heart failure and arrhythmia
Author(s) -
Bers Donald M.,
ChenIzu Ye
Publication year - 2015
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jp270133
Subject(s) - contractility , heart failure , medicine , cardiology , sodium calcium exchanger , homeostasis , cardiac function curve , diastole , cardiomyopathy , calcium , myocyte , chemistry , neuroscience , biology , blood pressure
This special issue, Sodium and calcium in heart, brings together three reviews (Clancy et al. 2015; Chen-Izu et al. 2015; Shattock et al. 2015) and several original studies focused on these themes. Heart disease is the most prevalent cause of death in the developed world. In order to improve therapeutic approaches to treat heart disease, a deeper understanding of the fundamental mechanisms underlying altered heart function in specific diseases like arrhythmias, ischaemia and heart failure (HF) is essential. Cardiac function is controlled by three dynamically interacting systems – electrical, Ca2+ signalling, and contractile. To integrate these systems and reveal the detailed physiological and pathological mechanisms of cardiac function requires state-of-the-art experimental and computational approaches that span multiple system scales, that is, spatial scales ranging from molecules to the organism and time scales ranging from picoseconds to days or even years.