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Co‐ordination of cough and swallow in vivo and in silico
Author(s) -
Pitts Teresa,
Morris Kendall,
Lindsey Bruce,
Davenport Paul,
Poliacek Ivan,
Bolser Donald
Publication year - 2012
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.2011.063362
Subject(s) - in silico , ordination , in vivo , chemistry , medicine , biology , biochemistry , genetics , ecology , gene
Coughing and swallowing are airway‐protective behaviours. The pharyngeal phase of swallowing prevents aspiration of oral material (saliva, food and liquid) by epiglottal movement, laryngeal adduction and clearing of the mouth and pharynx. Coughing is an aspiration‐response behaviour that removes material from the airway. Co‐ordination of these behaviours is vital to protect the airway from further aspiration‐promoting events, such as a swallowing during the inspiratory phase of coughing. The operational characteristics, primary strategies and peripheral inputs that co‐ordinate coughing and swallowing are unknown. This lack of knowledge impedes understanding and treatment of deficits in airway protection, such as the co‐occurrence of dystussia and dysphagia common in Parkinson's and Alzheimer's diseases, as well as stroke.