Dynamic characteristics of heart rate control by the autonomic nervous system in rats | Zendy

Mizuno Masaki | Zendy; Kawada Toru | Zendy; Kamiya Atsunori | Zendy; Miyamoto Tadayoshi | Zendy; Shimizu Shuji | Zendy; Shishido Toshiaki | Zendy; Smith Scott A. | Zendy; Sugimachi Masaru | Zendy

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Dynamic characteristics of heart rate control by the autonomic nervous system in rats

Author(s) -

Mizuno Masaki,

Kawada Toru,

Kamiya Atsunori,

Miyamoto Tadayoshi,

Shimizu Shuji,

Shishido Toshiaki,

Smith Scott A.,

Sugimachi Masaru

Publication year - 2010

Publication title -

experimental physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.925

H-Index - 101

eISSN - 1469-445X

pISSN - 0958-0670

DOI - 10.1113/expphysiol.2010.053090

Subject(s) - stimulation , autonomic nervous system , heart rate , transfer function , lag , sympathetic nervous system , medicine , baroreflex , endocrinology , blood pressure , computer network , computer science , electrical engineering , engineering

We estimated the transfer function of autonomic heart rate (HR) control by using random binary sympathetic or vagal nerve stimulation in anaesthetized rats. The transfer function from sympathetic stimulation to HR response approximated a second‐order, low‐pass filter with a lag time (gain, 4.29 ± 1.55 beats min −1 Hz −1 ; natural frequency, 0.07 ± 0.03 Hz; damping coefficient, 1.96 ± 0.64; and lag time, 0.73 ± 0.12 s). The transfer function from vagal stimulation to HR response approximated a first‐order, low‐pass filter with a lag time (gain, 8.84 ± 4.51 beats min −1 Hz −1 ; corner frequency, 0.12 ± 0.06 Hz; and lag time, 0.12 ± 0.08 s). These results suggest that the dynamic characteristics of HR control by the autonomic nervous system in rats are similar to those of larger mammals.

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