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Optogenetic experimentation on astrocytes
Author(s) -
Figueiredo M.,
Lane S.,
Tang F.,
Liu B. H.,
Hewinson J.,
Mari.,
Kasymov V.,
Souslova E. A.,
Chudakov D. M.,
Gourine A. V.,
Teschemacher A. G.,
Kasparov S.
Publication year - 2011
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.2010.052597
Subject(s) - optogenetics , channelrhodopsin , neuroscience , astrocyte , effector , biology , in vivo , microbiology and biotechnology , central nervous system
We briefly review the current literature where optogenetics has been used to study various aspects of astrocyte physiology in vitro and in vivo . This includes both genetically engineered Ca 2+ sensors and effector proteins, such as channelrhodopsin. We demonstrate how the ability to target astrocytes with cell‐specific viral vectors to express optogenetic constructs helped to unravel some previously unsuspected roles of these inconspicuous cells.