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Evidence for intestinal chloride secretion
Author(s) -
Murek Michael,
Kopic Sascha,
Geibel John
Publication year - 2010
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.2009.049445
Subject(s) - secretion , enterocyte , digestion (alchemy) , absorption (acoustics) , chloride , chemistry , medicine , endocrinology , biochemistry , biology , small intestine , chromatography , materials science , organic chemistry , composite material
Intestinal fluid secretion is pivotal in the creation of an ideal environment for effective enzymatic digestion, nutrient absorption and stool movement. Since fluid cannot be actively secreted into the gut, this process is dependent on an osmotic gradient, which is mainly created by chloride transport by the enterocyte. A pathological dysbalance between fluid secretion and absorption leads to obstruction or potentially fatal diarrhoea. This article reviews the widely accepted model of intestinal chloride secretion with an emphasis on the molecular players involved in this tightly regulated process.