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Glucose ingestion during endurance training in men attenuates expression of myokine receptor
Author(s) -
Akerstrom Thorbjorn C. A.,
KroghMadsen Rikke,
Petersen Anne Marie Winther,
Pedersen Bente Klarlund
Publication year - 2009
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.2009.048983
Subject(s) - myokine , ingestion , medicine , endocrinology , skeletal muscle , endurance training , receptor
Glucose ingestion during exercise attenuates the release of the myokine interleukin‐6 (IL‐6) from working skeletal muscle, which results in a diminished increase in plasma IL‐6. Interleukin‐6 receptor α (IL‐6Rα) expression in skeletal muscle is induced by acute exercise, mediated in part by an increased IL‐6 concentration in the bloodstream. We hypothesized that endurance training would increase the density of IL‐6Rα in skeletal muscle and that glucose ingestion would attenuate the effect. Nine subjects performed 10 weeks of one‐legged knee‐extensor training. They trained one leg (Glc‐leg) while ingesting a glucose solution (Glc) and ingested a placebo (Plc) while training the other leg (Plc‐leg). Endurance training increased peak power by ∼14% and reduced the exercise‐induced gene expression of IL‐6 and IL‐6Rα in skeletal muscle and IL‐6 plasma concentration. The IL‐6Rα density increased to a lesser extent in the Glc‐leg, suggesting that glucose ingestion attenuates the effect of training on IL‐6Rα by blunting the IL‐6 response. We conclude that glucose ingestion during endurance training attenuates the increase in IL‐6Rα density.