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Influence of central command on cerebral blood flow at the onset of exercise in women
Author(s) -
Sato Kohei,
Moriyama Mayumi,
Sadamoto Tomoko
Publication year - 2009
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.2009.048587
Subject(s) - cerebral blood flow , middle cerebral artery , medicine , cardiology , elbow , blood flow , elbow flexion , heart rate , cardiac output , cerebral circulation , hemodynamics , anatomy , blood pressure , ischemia
This study evaluated the role of central command in the regulation of common carotid artery blood flow and middle cerebral artery mean flow velocity ( V MCA ) at the onset of arm exercise. Eleven young women performed 2 min voluntary elbow flexion and extension exercise with no load (VOL) that was considered to activate both central command and the muscle mechanoreflex, and 2 min passive elbow flexion and extension exercise (PAS) that was considered to activate only the muscle mechanoreflex. Immediately before the onset of VOL, and V MCA began to increase from the baseline and peaked 5 s thereafter (mean ± s.d. ; 20 ± 5 and 14 ± 5%, respectively; P < 0.05). Also, VOL increased heart rate (9 ± 2%; P < 0.05) and cardiac output (16 ± 3%; P < 0.05). Indexes of the cerebrovascular resistance (MAP/ and MAP/ V MCA ) were reduced at the onset of VOL (−13 ± 4 and −12 ± 4%, respectively; P < 0.05). However, there were no significant changes in these parameters during PAS. These results suggest that central command plays an important role in the increase of cerebral blood flow at the onset of voluntary exercise.