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Neurohumoral mechanisms in deoxycorticosterone acetate (DOCA)–salt hypertension in rats
Author(s) -
Yemane Henok,
Busauskas Marius,
Burris Sarah K.,
Knuepfer Mark M.
Publication year - 2010
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.2008.046334
Subject(s) - vasopressin , endocrinology , medicine , sympathetic nervous system , hyperaldosteronism , endothelin receptor , aldosterone , blood pressure , receptor
This brief review describes the role of neural and non‐neural mechanisms during different phases of deoxycorticosterone acetate (DOCA)–salt hypertension. There are contradictory data for and against a role of the sympathetic nervous system and neurohumoral agents, including endothelin and vasopressin. Elucidating the factors responsible for DOCA–salt hypertension will be helpful in understanding the causes of hypertension resulting from hypervolaemia, hyperaldosteronism and high salt intake.