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Angiotensin II receptor signalling
Author(s) -
Daniels Derek,
Yee Daniel K.,
Fluharty Steven J.
Publication year - 2007
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.2006.036897
Subject(s) - angiotensin ii , homeostasis , renin–angiotensin system , body fluid , receptor , angiotensin ii receptor type 1 , thirst , signal transduction , angiotensin receptor , endocrinology , medicine , transduction (biophysics) , biology , neuroscience , chemistry , microbiology and biotechnology , biochemistry , blood pressure
Angiotensin II plays a key role in the regulation of body fluid homeostasis. To correct body fluid deficits that occur during hypovolaemia, an animal needs to ingest both water and electrolytes. Thus, it is not surprising that angiotensin II, which is synthesized in response to hypovolaemia, acts centrally to increase both water and NaCl intake. Here, we review findings relating to the properties of angiotensin II receptors that give rise to changes in behaviour. Data are described to suggest that divergent signal transduction pathways are responsible for separable behavioural responses to angiotensin II, and a hypothesis is proposed to explain how this divergence may map onto neural circuits in the brain.