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Systemic, cellular and molecular analysis of chemoreflex‐mediated sympathoexcitation by chronic intermittent hypoxia
Author(s) -
Prabhakar Nanduri R.,
Dick Thomas E.,
Nanduri Jayasri,
Kumar Ganesh K.
Publication year - 2007
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.2006.036434
Subject(s) - chemoreceptor , hypoxia (environmental) , carotid body , reflex , peripheral chemoreceptors , sympathetic nervous system , neuroscience , stimulus (psychology) , biology , endocrinology , medicine , electrophysiology , psychology , chemistry , blood pressure , receptor , oxygen , organic chemistry , psychotherapist
Patients with recurrent apnoeas exhibit autonomic abnormalities manifested as persistent increase in sympathetic nerve activity (SNA). Several studies suggest that chronic intermittent hypoxia (CIH) resulting from recurrent apnoeas is a major stimulus for evoking autonomic morbidity. Although it has been proposed that CIH, by way of activating the chemoreceptor reflex, leads to sympathetic excitation, the underlying mechanisms are incompletely understood. Studies on experimental models have provided new insights into the mechanisms associated with CIH‐evoked sympathoexcitation. The purpose of this article is to highlight recent information on systemic, cellular and molecular analysis of the effects of CIH on chemoreceptor‐mediated sympathoexcitation. Chronic intermittent hypoxia exerts two major effects on the chemoreceptor reflex: (a) augmentation of the carotid body and sympathetic effector responses to acute hypoxia; and (b) induction of long‐lasting activation of both the sensor and the effector that persists several hours after termination of CIH. Available evidence indicates that CIH may facilitate processing of chemoreceptor afferent information at the central nervous system. Recent studies suggest that reactive oxygen species‐mediated signalling is a major cellular mechanism, and transcriptional activation by hypoxia‐inducible factor‐1 is one of the critical molecular mechanisms underlying chemoreceptor‐mediated sympathoexcitation by CIH.