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Variations in carotid arterial compliance during the menstrual cycle in young women
Author(s) -
Hayashi Koichiro,
Miyachi Motohiko,
Seno Natsuki,
Takahashi Kouki,
Yamazaki Ken,
Sugawara Jun,
Yokoi Takashi,
Onodera Sho,
Mesaki Noboru
Publication year - 2006
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.2005.032011
Subject(s) - luteal phase , medicine , arterial stiffness , menstrual cycle , peripheral , follicular phase , blood pressure , cardiology , brachial artery , pulse wave velocity , lumen (anatomy) , elasticity (physics) , common carotid artery , carotid arteries , endocrinology , hormone , materials science , composite material
The effect of menstrual cycle phase on arterial elasticity is controversial. In 10 healthy women (20.6 ± 1.5 years old, mean ± s.d. ), we investigated the variations in central and peripheral arterial elasticity, blood pressure (carotid and brachial), carotid intima–media thickness (IMT), and serum oestradiol and progesterone concentrations at five points in the menstrual cycle (menstrual, M; follicular, F; ovulatory, O; early luteal, EL; and late luteal, LL). Carotid arterial compliance (simultaneous ultrasound and applanation tonometry) varied cyclically, with significant increases from the values seen in M (0.164 ± 0.036 mm 2 mmHg −1 ) and F (0.171 ± 0.029 mm 2 mmHg −1 ) to that seen in the O phase (0.184 ± 0.029 mm 2 mmHg −1 ). Sharp declines were observed in the EL (0.150 ± 0.033 mm 2 mmHg −1 ) and LL phases (0.147 ± 0.026 mm 2 mmHg −1 ; F = 8.51, P < 0.05). Pulse wave velocity in the leg (i.e. peripheral arterial stiffness) did not exhibit any significant changes. Fluctuations in carotid arterial elasticity correlated with the balance between oestradiol and progesterone concentrations. No significant changes were found in carotid and brachial blood pressures, carotid artery lumen diameter, or IMT throughout the menstrual cycle. These data provide evidence that the elastic properties of central, but not peripheral, arteries fluctuate significantly with the phases of the menstrual cycle.