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Genetic analysis of complex cardiovascular traits in the spontaneously hypertensive rat
Author(s) -
Pravenec Michal,
Křen Vladimír
Publication year - 2005
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.2004.029322
Subject(s) - phenotype , identification (biology) , quantitative trait locus , biology , genetics , genetic linkage , trait , inbred strain , genetic analysis , computational biology , gene , botany , computer science , programming language
Identification of the genetic determinants of common diseases is a major challenge for current biomedical research. Combining linkage analyses of essentially monogenic cis ‐regulated expression phenotypes with oligogenic intermediate physiological phenotypes represents a promising approach for identification of quantitative trait loci at the molecular level. In the present review, a genetic analysis of cardiovascular phenotypes studied at several levels of complexity in rat recombinant inbred strains is described.