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Paroxetine administration to influence human exercise capacity, perceived effort or hormone responses during prolonged exercise in a warm environment
Author(s) -
Strachan A. T.,
Leiper J. B.,
Maughan R. J.
Publication year - 2004
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.2004.027839
Subject(s) - paroxetine , placebo , prolactin , medicine , serotonin , endocrinology , reuptake inhibitor , hormone , psychology , alternative medicine , receptor , pathology
The purpose of the experiment was to examine whether selective serotonin (5‐HT) re‐uptake transporter blockade by paroxetine has any effect on perceived effort (RPE) during exercise or the time to reach volitional fatigue and on the prolactin and cortisol responses during prolonged exercise performed in a warm environment. Eight healthy males performed two cycle rides to exhaustion in a warm (32°C) environment at 60% of maximum oxygen uptake. Paroxetine (20 mg) or placebo was administered 5 h before exercise trials in a randomised double blind fashion. Time to exhaustion was not significantly influenced by administration of paroxetine: median (range) time to exhaustion was 93.3 (76.2–175.0) min on the placebo trial and 92.5 (66.0–151.0) min on the paroxetine trial. Rectal temperature was higher at rest and throughout exercise on the paroxetine trial. The serum concentrations of prolactin and cortisol were determined throughout exercise as peripheral markers of central 5‐HT activity. RPE increased over time but was not influenced by paroxetine administration. Prolactin and cortisol levels increased over time but paroxetine administration did not influence the hormone responses during exercise. In conclusion, acute administration of paroxetine failed to alter RPE, exercise capacity or the response of the determined peripheral hormone markers of central 5‐HT activity during prolonged exercise in a warm environment.