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The relation between local cerebral blood flow and extracellular glucose concentration in rat striatum
Author(s) -
Fillenz M,
Lowry JP
Publication year - 1998
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1998.sp004107
Subject(s) - extracellular , chloral hydrate , chemistry , extracellular fluid , cerebral blood flow , endocrinology , glucose oxidase , medicine , striatum , sodium , pentobarbital , saline , anesthesia , biochemistry , biosensor , dopamine , organic chemistry
The effect of anaesthetics on the relation between local cerebral blood flow (rCBF) and extracellular glucose was studied in rat striatum. Cerebral blood flow was measured using the hydrogen clearance method and extracellular glucose using an implanted glucose oxidase‐based biosensor. Rats were given an intraperitoneal (i.p.) injection of either sodium pentobarbitone (60 mg kg‐1) or chloral hydrate (350 mg kg‐1). The effect of the i.p. injection, as demonstrated by an i.p. saline injection, was a brief increase in rCBF accompanied by a decrease in glucose. Sodium pentobarbitone produced a decrease in both rCBF and glucose, whereas chloral hydrate caused a decrease in glucose but an increase in rCBF. These findings show a dissociation between rCBF and extracellular glucose and suggest that glucose in the extracellular compartment is not derived directly from the blood vascular compartment.