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The effects of buspirone on perceived exertion and time to fatigue in man
Author(s) -
Marvin G,
Sharma A,
Aston W,
Field C,
Kendall MJ,
Jones DA
Publication year - 1997
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1997.sp004080
Subject(s) - buspirone , placebo , agonist , serotonergic , perceived exertion , medicine , crossover study , endocrinology , psychology , heart rate , serotonin , blood pressure , receptor , alternative medicine , pathology
Male subjects exercised at 80% maximal rate of O2 uptake (VO2,max) following oral administration of either placebo or the partial 5‐HT1A agonist buspirone (45 mg), using a paired design. Ratings of perceived exertion were higher following buspirone and time to volitional fatigue (median and inter‐quartile range) fell significantly by approximately a third from 26 min (24‐30 min) on placebo to 16 min (11‐19 min) following buspirone. Serum prolactin was significantly elevated following buspirone administration, indicating increased hypothalamic 5‐HT1A receptor stimulation. There were no significant differences in blood lactate or serum glucose between the trials. This study supports the possible central modulation of exercise tolerance by serotonergic pathways, although a role for dopamine cannot be excluded.