Premium
Glycosaminoglycan depletion greatly raises the hydraulic permeability of rabbit joint synovial lining
Author(s) -
Scott D,
Coleman PJ,
Mason RM
Publication year - 1997
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1997.sp004050
Subject(s) - glycosaminoglycan , synovial fluid , hyaluronidase , synovial membrane , permeability (electromagnetism) , hyaluronic acid , in vivo , osteoarthritis , chemistry , cartilage , anatomy , arthritis , microbiology and biotechnology , medicine , pathology , immunology , biology , biochemistry , enzyme , alternative medicine , membrane
The hydraulic resistance of the synovial lining of a joint is important for retention of intraarticular lubricant. The resistance has been attributed to synovial interstitial glycosaminoglycans. This was tested by depletion of hyaluronan and chondroitin sulphates from synovium in five rabbit knees in vivo under anaesthesia, using testicular hyaluronidase. The enzyme raised synovial permeability to fluid 5‐ to 7‐fold‐substantially more, in fact, than predicted by a recent model. The results prove that hyaluronan and/or chondroitin sulphate are important sources of hydraulic resistance in synovium.