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Dysfunction of the endothelial nitric oxide signalling pathway in diabetes and hyperglycaemia
Author(s) -
Sobrevia L,
Mann GE
Publication year - 1997
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/expphysiol.1997.sp004038
Subject(s) - adenosine , nitric oxide , vasodilation , purinergic receptor , hyperpolarization (physics) , endothelial dysfunction , endothelium , medicine , microbiology and biotechnology , endocrinology , arginine , chemistry , purinergic signalling , biology , adenosine receptor , biochemistry , agonist , receptor , nuclear magnetic resonance spectroscopy , organic chemistry , amino acid
1. Vasodilatation induced by adenosine is mediated through the activation of A2‐purinoceptors in endothelial and smooth muscle cells. 2. Adenosine induces a rapid and transient membrane hyperpolarization in endothelial cells. 3. Acute exposure to adenosine or A2‐purinoceptor agonists activates the L‐arginine‐NO signalling pathway in human endothelial cells in vitro.